Allele/Variant

Tg(Rb1)1Blg

Species
Mus musculus
Symbol
Tg(Rb1)1Blg
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • mgRB
  • RBlox1
Description
This transgene consists of the 1.3-kb murine Rb1 promoter region, the first exon and intron fused, in frame, to exons 2 to 27 of the mouse Rb1 cDNA and a human growth hormone cassette that provides splicing and polyadenylation signals at the 3' end. LoxP sites were inserted into the first intron and between the Rb1 stop codon and the human growth hormone, in a tandem orientation, to allow excision in the presence of Cre recombinase. Only low levels of protein were expressed, demonstrating that this transgene is hypomorphic. Six founders were generated and line 1 was selected as the representative line.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations