Unc79^Lwt

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Species

Mus musculus

Symbol

Unc79^Lwt

Category

allele

Allele of gene

Unc79

Transgenic Constructs

None

Synonyms

• Unc79^Lwt
• Unc79^Mlca3

Description

The dominant behavioral phenotype of one of the independent loci, Lightweight (Lwt), results from a nonsense mutation in the mouse homolog of the C. elegans unc-79 gene. The mutation results in a G-T transversion at amino acid position 1292 leading to the conversion of a glutamic acid residue to a premature stop codon in exon 27. Immunoblot analysis indicates an absence of the expected band at 290 kDa in mutant versus wildtype homogenates.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations