Cacna1a^Wb

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Species

Mus musculus

Symbol

Cacna1a^Wb

Category

allele

Allele of gene

Cacna1a

Transgenic Constructs

None

Synonyms

None

Description

A G-to-T transversion at coding cDNA nucleotide 4189 (c.4189G>T in GenBank NM_007578) leads to an arginine-to-leucine substitution at amino acid position 1303 (p.R1303L), in the highly conserved, positively charged transmembrane segment S4 of repeat III of the encoded protein. Levels of transcript and protein encoded by the gene are similar in brains of mutant and wild-type mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations