Allele/Variant

Tg(YAC353G6)W7Hay

Species
Mus musculus
Symbol
Tg(YAC353G6)W7Hay
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • C6R7
  • YAC353G6
Description
A YAC containing a full-length human huntingtin gene was modified with a 133 CAG repeat expansion in exon 1 and a mutation in exon 13, at position 586, which encodes the caspase-6 cleavage site. Founder line W7 (C6R7) was subsequently established. Caspase-6 cleavage products are not detected in brain lysates by Western blot.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations