Allele/Variant

Braftm1.1Wds

Species
Mus musculus
Symbol
Braftm1.1Wds
Category
allele
Allele of gene
Braf
Transgenic Constructs
None
Synonyms
  • Brafexon3-
Description
Exon 3 was removed by cre mediated recombination in the germline. Deletion of exon 3 was expected to cause a reading frame shift and introduce a translational stop codon at position 132, truncating the RBD, CRD and kinase domains. Western blot confirmed ablation of the protein.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
embryonic growth retardationMGI
embryonic lethality during organogenesis, complete penetranceMGI
increased neuron apoptosisMGI
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Disease Associations