Allele/Variant

Ccn1tm2Lfl

Species
Mus musculus
Symbol
Ccn1tm2Lfl
Category
allele
Allele of gene
Ccn1
Transgenic Constructs
None
Synonyms
  • CCN1dm
Description
Exon 1 and half of exon 2 were replaced by a DNA cassette containing the Cyr61 promoter, the dm (apoptosis defective mutant allele) open reading frame (containing the signal sequence, IGFBP, VWC, variable, TSP and CT domains with H1 and H2 sites of Cyr61) and a neo cassette. The dm open reading frame is defective in apoptotic synergism with TNFalpha. The absence of protein product was confirmed by western blot analysis following serum-stimulation.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations