Allele/Variant

Tg(Thy1-APP)4Vln

Species

Mus musculus

Symbol

Tg(Thy1-APP)4Vln

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

APP/Wt
APP/Wt/4

Description

cDNA encoding the human wild-type amyloid precursor protein (695 isoform) was cloned into the pTSC vector in the mouse Thy1 gene. The linearized minigene was injected into prenuclear embryos from FVB/N females. Human APP protein is expressed in hippocampus, parietal and frontal cortices at 2-5 times the endogenous APP levels, at lower levels in olfactory bulb and thalamus, and at very low levels in the cerebellum.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

APP (Hsa)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype	Annotation details	Source	References
No records match query. Try removing filters.

Showing 0 - 0 of 0 rows

per page

Disease Associations

Association	Disease Qualifier	Disease	Annotation details	Evidence	Source	References
No records match query. Try removing filters.

Showing 0 - 0 of 0 rows

per page