Allele/Variant

Tg(Thy1-APPSw)1Vln

Species

Mus musculus

Symbol

Tg(Thy1-APPSw)1Vln

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

APP/Sw/1
Tg(Thy1-APP*K670N*M671L)1Vln

Description

cDNA encoding the human Swedish (K670N,M671L) amyloid precursor protein variant (770 isoform) was cloned into the pTSC vector in the mouse Thy1 gene. The linearized minigene was injected into prenuclear embryos from FVB/N females. Human mutant APP protein is expressed in hippocampus, parietal and frontal cortices at 2-5 times the endogenous APP levels, at lower levels in olfactory bulb and thalamus, and at very low levels in the cerebellum.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

APP (Hsa)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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