Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Col2a1-Mef2c/en)1Eno
MGI:3718996Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Col2a1-Mef2c/en)1Eno

Species
Mus musculus
Symbol
Tg(Col2a1-Mef2c/en)1Eno
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • Col2-MEF2C-Engrailed
Description
This transgene expresses a fusion protein of the murine Mef2c DNA-binding domain and the Drosophila Engrailed repressor in proliferating chondrocytes under the control of the murine Col2a1 promoter. This Mef2c-engrailed fusion protein inactivates all Mef2 proteins by preventing DNA binding and creating transcriptionally inactive heterodimers with wild-type Mef2 proteins.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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