Allele/Variant

Tg(DMD-APP*)18Neve

Species
Mus musculus
Symbol
Tg(DMD-APP*)18Neve
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • FLAGC100
Description
A fragment consisting composed of the sequence ot the terminal 100 amino acids of the beta-amyloid precursor protein APP gene (C100, referred to as C104 in J:105050 which states that the transgene contains the terminal 100 amino acids of APP) was inserted into a plasmid encoding the neural-specific dystrophin (DMD) promoter. The vector also contained the SV40 early splice and polyadenylation sequences. A hydrophilic 10-amino acid FLAG sequence was engineered onto the aminoterminus of the C100 fragment. The construct was injected into (C57BL/6 x SJL)F2 fertilized eggs. Six founder mice were identified, 5 showing higher expression than the identified line 2. Line 18 was chosen to represent the higher expressing transgenic lines. RT-PCR revealed expression of the FLAGC100 in brains of all transgenic lines.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
    Disease
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