Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Tg(CMV-IghvaD11)DCat
- Species
- Mus musculus
- Symbol
- Tg(CMV-IghvaD11)DCat
- Category
- allele
- Allele of gene
- None
- Transgenic Constructs
- Synonyms
- AD09 D
- AD11-VH
- Description
- The transgenic construct included a recombined Igh variable region encoding the heavy chain of the rat anti-nerve growth factor monoclonal antibody, alphaD11. The constant region of the human immunoglobulin heavy region (IGH@) was included downstream to enable the detection of the transgenic antibodies against murine immunoglobulins. The early region promoter (-601 to -16) of human CMV reportedly drove expression of the transgene in non-neuronal tissures as well as in neuronal tissues including the cortex, hippocampus, thalamus, spinal cord, retina, olfactory bulb, and cerebellum. Line D has lower transgene expression than line C.
- Additional Information
- Literature
Transgenic Constructs
This allele contains 1 transgenic construct- Symbol
- Expressed Components
- Knock-down Targets
- None
- Regulatory Regions
- None