Ophn1^tm2Bill

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Species

Mus musculus

Symbol

Ophn1^tm2Bill

Category

allele

Allele of gene

Ophn1

Transgenic Constructs

None

Synonyms

• Ophn1 floxed allele

Description

A cassette flanked by mutant loxP sites was constructed with the entire coding sequence of the target gene oriented in one direction and a second "marker" gene orientated in the opposite direction. This construct was inserted into the first coding exon so that gene expression was simultaneously disrupted and rescued by the inserted cassette. The sequence between the mutant loxP alleles is inverted upon Cre recombinase activity, leading to inactivation of the gene coding sequence and expression of the marker gene.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations