Arhgef9^tm1.1Betz

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Species

Mus musculus

Symbol

Arhgef9^tm1.1Betz

Category

allele

Allele of gene

Arhgef9

Transgenic Constructs

None

Synonyms

• Collybistin knock-out

Description

Transfection of ES cells with a cre construct was used to remove exon 5 along with an inserted neo cassette. Exon 5 encodes part of the catalytic RhoGEF domain. Its deletion and resulting frameshift are predicted to destroy the function of the protein and eliminate the entire C-terminus. The absence of full length and truncated protein products was confirmed by western blot on brain homogenates using either a monoclonal specific for the N-terminus or polyclonal antibody against Arhgef9.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations