Allele/Variant

Tg(Th-SNCA*)1702Yosh

Species
Mus musculus
Symbol
Tg(Th-SNCA*)1702Yosh
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • syn130m
  • Syn130m-1702
Description
The transgene construct contains the human alpha synuclein sequence with an A53T point mutation and a stop codon engineered at residue 130 which results in a truncated protein lacking the last 10 amino acids at the C-terminus. This sequence is under control of the rat tyrosine hydroxylase (Th) promoter (9 kb of 5' flanking region of the rat Th gene). The purified construct was injected into pronuclei of fertilized (C57BL/6 x C3H)F1 eggs. Copy number is estimated to be ~30. Expression of the transgene product is detected in the midbrain in soma and axons of neurons in the substantia nigra pars compacta.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations