Allele/Variant

Tg(Camk2a-DISC1)10Asaw

Species
Mus musculus
Symbol
Tg(Camk2a-DISC1)10Asaw
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • DN_DISC1
  • DN-DISC1
Description
The Camk2a promoter drives the expression of a truncated human DISC1 open reading frame that produces amino acids 1 through 597. This truncated protein is thought to function as a dominant negative. The transgene is expressed preferentially in neonatal stages, especially in pyramidal neurons of the dentate gyrus, and does not interfere with endogenous gene expression from Disc1. This is the low expressing line.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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