Allele/Variant

Prox1tm3(cre/ERT2)Gco

Species
Mus musculus
Symbol
Prox1tm3(cre/ERT2)Gco
Category
allele
Allele of gene
Prox1
Transgenic Constructs
Synonyms
  • Prox-1CreERT2
  • Prox1-CreERT2
Description
A synthetic splice acceptor site, exons 3 and 4, and an IRES-cre/ERT2 cassette were inserted into intron 2 along with a neo and thymidine kinase cassettes. Insertion was confirmed by Southern blot analysis and through crosses with reporter lines. Expression of cre is tamoxifen inducible and recapitulates endogenous promoter activity specifically in the central nervous system, eye, liver, heart, branchial arches and lymphatic endothelial cells.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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