Unc5b^tm1Matl

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Species

Mus musculus

Symbol

Unc5b^tm1Matl

Category

allele

Allele of gene

Unc5b

Transgenic Constructs

None

Synonyms

• Unc5b^bGal

Description

A secretory trap vector possessing a splice acceptor followed by a linker protein, a transmembrane domain, beta-geo, an IRES domain, and a placental alkaline phosphatase reporter gene was targeted to intron 2 of the gene locus. As a result of integration, exons 1 and 2 splice to the vector sequences resulting in a mutant fusion protein with no biological activity. Northern blots of RNA from E10.5 embryos indicated no wild-type transcript while RT-PCR indicated very low levels (under 3%) of wild-type transcript.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations