Version: 8.0.0
Date: Tue Jan 28 2025
Tg(CD207-cre)1Dhka
MGI:3761645Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(CD207-cre)1Dhka

Species
Mus musculus
Symbol
Tg(CD207-cre)1Dhka
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • huLangerinCretg+
  • Langerin-Cre
Description
A cre recombinase gene optimized for mammalian codon usage was inserted right after the ATG of exon 1 in a human BAC, which was then injected into oocytes. Insertion of the cre gene was confirmed by PCR on genomic DNA. Cre expression is restricted to all epidermis MHC-II+CD11c+ Langerhans cells but not other CD207 expressing cells.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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