Allele/Variant

Mdm2tm1Ypz

Species
Mus musculus
Symbol
Mdm2tm1Ypz
Category
allele
Allele of gene
Mdm2
Transgenic Constructs
None
Synonyms
  • Mdm2C462A
Description
A loxP site flanked neomycin resistance gene cassette was inserted into intron 10 and cystine codon 462 (TGT) in exon 12 was changed to alanine (GCC) (p.C462A). This amino acid substitution abolishes E3 ubiquitin ligase activity without affecting DNA binding ability. The neo cassette was subsequently removed by Cre-mediated recombination.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

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    Disease Associations

    Association
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