Ttn^tm1Mgot

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Species

Mus musculus

Symbol

Ttn^tm1Mgot

Category

allele

Allele of gene

Ttn

Transgenic Constructs

None

Synonyms

• N2B

Description

Exon 49, which encodes the N2B extensible region, was replaced with a FRT-flanked neomycin resistance cassette. Chimeric mice were mated with a Flp expressing deleter strain to remove the neomycin cassette, leaving a single FRT site. The deletion of exon 49 leads to splicing of exon 48 to exon 50, which maintains the ORF and produces a mutant form of the protein that lacks a N2B region. The N2B-deficient protein is integrated properly into sarcomeres as demonstrated by immunofluorescence labeling.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations