Allele/Variant

Fn1tm4Hyn

Species
Mus musculus
Symbol
Fn1tm4Hyn
Category
allele
Allele of gene
Fn1
Transgenic Constructs
None
Synonyms
  • EIIIA/EIIIB-double-null
  • EIIIA-EIIIB-
Description
ES cells from homozygous Fn1tm1Ksek male mouse in which exon EDB (EIIIB) was deleted and replaced with a singe loxp site was isolated and targeted with the same construct used in Fn1tm1Bwg. Following homologous recombination and transient cre-mediated recombination, a single loxp site was left in place of the exon encoding the EIIIA domain. Northern and Western blot confirmed the absence of EIII1 and EIIIB mRNA and protein and that deletion of both of those exons did not compromise the expression of FN mRNA and protein, nor the deposition of FN into the matrix.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
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