Version: 8.0.0
Date: Tue Jan 28 2025
Gt(ROSA)26Sortm2(cre/ERT2)Brn
MGI:3764519
Allele of Gt(ROSA)26Sor
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Gt(ROSA)26Sortm2(cre/ERT2)Brn

Species
Mus musculus
Symbol
Gt(ROSA)26Sortm2(cre/ERT2)Brn
Category
allele
Allele of gene
Gt(ROSA)26Sor
Transgenic Constructs
Synonyms
  • ERT2
  • Gt(ROSA)26Sortm2(cre/Esr1)Brn
Description
The endogenous locus was modified by insertion into the first intron of a construct containing the rabbit beta-globin 3' splice site followed by the cre/ERT2 fusion gene, which encodes Cre recombinase joined to a mutant hormone-binding domain of the human estrogen receptor that is activated by 4-hydroxytamoxifen (4-OHT), but not by the natural ER ligand 17-beta-estradiol. The fusion gene is followed by the rabbit beta-globin polyadenylation signal and a PGK-puro (puromycin resistance) cassette. Western blot analysis confirmed expression of the cre/ERT2 fusion product.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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