Version: 8.0.0
Date: Tue Jan 28 2025
Akap5tm1Gsm
MGI:3765995
Allele of Akap5
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Akap5tm1Gsm

Species
Mus musculus
Symbol
Akap5tm1Gsm
Category
allele
Allele of gene
Akap5
Transgenic Constructs
None
Synonyms
  • AKAP150 delta A
  • AKAP150delta36
Description
A stop codon (TAG) replaced the codon for Leu710 (TTA) (L710X), truncating the last 36 residues that are important for binding to protein kinase A (PKA). A loxP-flanked neomycin resistance cassette was also inserted downstream of the lone coding exon. After germ line transmission, the neomycin resistance cassette was removed by crossing with cre-transgenic mice. Western blots for PKA subunits from postsynaptic densities of the forebrain indicated reduced levels of protein, confirming mutation of the targeted gene.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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