Tlr7^rsq1

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Species

Mus musculus

Symbol

Tlr7^rsq1

Category

allele

Allele of gene

Tlr7

Transgenic Constructs

None

Synonyms

None

Description

The rsq1 phenotype was identified in an ENU mutagenesis screen for mutants with impaired response to Toll-like receptor (TLR) ligands. The mutation is a C-to-T transition at nucleotide position 391 of the gene (Genbank Accession NM_133211) resulting in replacement of threonine by isoleucine at amino acid position 68, in the first leucine-rich repeat (LRR) of the receptor.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations