Version: 8.0.0
Date: Tue Jan 28 2025
Tg(NPHS2-rtTA,tetO-cre)1Holt
MGI:3767326Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(NPHS2-rtTA,tetO-cre)1Holt

Species
Mus musculus
Symbol
Tg(NPHS2-rtTA,tetO-cre)1Holt
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • JRC-CRE
Description
A rtTA gene modified to respond to less doxycycline was placed under the control of the human NPHS2 gene, which is only expressed in the podocytes of the kidney. In the same vector, a modified CMV promoter with a rtTA responsive element was used to drive the expression of cre recombinase. Sixteen founder mice were created, and one was selected for further breeding based on the doxycycline-induced expression of cre recombinase that was only detected in kidney podocyte cells.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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