Allele/Variant

Tgfbr1tm1Mulm

Species
Mus musculus
Symbol
Tgfbr1tm1Mulm
Category
allele
Allele of gene
Tgfbr1
Transgenic Constructs
None
Synonyms
  • ALK5KI
Description
The coding region was replaced with one containing a A to C substitution in exon 4 resulting in the substitution of alanine for aspartic acid at position 266 (D266A). This mutation prevents SMAD2 and SMAD3 activation but does not affect interacts with Acvrl1. RT-PCR analysis on spleen and liver was used to confirm the expression of the modified transcript.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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