Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Tg(Cd3d-Il5)NJ.1638Nal
- Species
- Mus musculus
- Symbol
- Tg(Cd3d-Il5)NJ.1638Nal
- Category
- allele
- Allele of gene
- None
- Transgenic Constructs
- Synonyms
- IL-5tg
- NJ.1638
- Description
- This construct was created by fusing in frame a 170-bp fragment from the 5' end of IL-5 cDNA with the remaining portion of the genomic IL-5 gene. This minigene has no upstream flanking sequences but has all of the introns of the gene as well as 1 .2 kb of downstream flanking sequence. To drive expression of the transgene in T cells, a promoter and tissue-specific enhancer derived from the murine CD3d gene was included upstream. Three founding lines (NJ.759, NJ.1638, NJ.1643) were created with one chosen for further studies. High levels of circulating IL-5 were detected in the sera of transgenic mice but not in wild-type mice.
- Additional Information
- Literature
Transgenic Constructs
This allele contains 1 transgenic construct- Symbol
- Expressed Components
- Knock-down Targets
- None
- Regulatory Regions
- None