Allele/Variant

Tg(Prnp-MAPT*P301S)PS19Vle

Species
Mus musculus
Symbol
Tg(Prnp-MAPT*P301S)PS19Vle
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • P301S tau (line PS19)
  • PS19 Tg
Description
The transgene construct contains the P301S mutant human microtubule-associated protein tau, MAPT, under the direction of the mouse prion protein, Prnp, promoter. The expression of the mutant human MAPT is 5-fold higher than the expression of the endogenous mouse Mapt protein. Transgene insertion occurred on Chr 3, causing a 249 Kb deletion.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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