Tg(Thy1-MAPT*P301L)2Vln

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Species

Mus musculus

Symbol

Tg(Thy1-MAPT*P301L)2Vln

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

• tau-4R/2N-P301L
• Tau.P301L

Description

A human MAPT cDNA encoding the longest tau isoform of 441 amino acids containing four repeats, with 2 N-terminal inserts, and also carrying an engineered mutation to alter codon 301 from one encoding proline to encoding leucine, was inserted into a murine Thy1 expression vector. Expression of the mutant human tau (MAPT*P301L) protein was detected in layers II, V and VI of the neocortex, in layer III of the entorhinal cortex, in thd basolateral amygdala, hippocampus, zona incerta of the thalamus, brain stem nuclei and spinal cord.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations