Allele/Variant

Mapttm1(MAPT)Vln

Species
Mus musculus
Symbol
Mapttm1(MAPT)Vln
Category
allele
Allele of gene
Mapt
Transgenic Constructs
None
Synonyms
  • tau-KOKI
Description
A human MAPT cDNA encoding the longest tau isoform of 441 amino acids containing four repeats, with 2 N-terminal inserts replaced the endogenous mouse gene. Endogenous mouse Mapt protein is not expressed, and the inserted human gene is expressed in brain driven by a murine Thy1 promoter beginning at P15.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal axon extension
MGI
abnormal dendrite morphology
MGI
abnormal hippocampus pyramidal cell morphology
MGI
abnormal motor coordination/balanceMGI
decreased anxiety-related response
MGI
enhanced long-term object recognition memory
MGI
enlarged hippocampus
MGI
increased cell proliferation
MGI
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Disease Associations