Ncoa6^tm2Jxu

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Species

Mus musculus

Symbol

Ncoa6^tm2Jxu

Category

allele

Allele of gene

Ncoa6

Transgenic Constructs

None

Synonyms

• NCoA6^L2m

Description

Nucleotide substitution was used to convert the LSQLL motif in exon 9 encoded by TTAAGCCAACTTCTT to GCAAGCCAAGCTCTT to change the motif to ASQAL. This modification results in an abrogation of protein protein interactions with Nr1h3 and Esr1. A floxed neo cassette was inserted upstream of exon 9 and subsequently removed by cre-mediated recombination. The expression of the modified protein was confirmed by western blot analysis on liver extracts.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations