Tln1^tm4.1Crit

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Species

Mus musculus

Symbol

Tln1^tm4.1Crit

Category

allele

Allele of gene

Tln1

Transgenic Constructs

None

Synonyms

• Tln1^fl

Description

Coding exons one through four (second through fifth exons) are flanked by loxP sites. This allele was generated by in vivo, Cre recombinase-mediated deletion of a loxP-flanked neomycin resistance cassette from the first intron of Tln1^tm4Crit in cre transgenic embryos homozygous for the latter allele (personal communication). Talin expression can be ablated in specific cell/tissue types by crossing homozygous mice with appropriate cre transgenic mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations