Allele/Variant

Tg(HIV)26Aln

Species
Mus musculus
Symbol
Tg(HIV)26Aln
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • AIDS Tg
  • T26
Description
A noninfectious provirus transgene was engineered from an infectious clone of an integrated HIV virus (pNL4-3) by deleting 3.1 kb of sequence between the Sphl site at base position 1443 and the Ball site at position 4551 (Fig. 1A). The in-frame deletion of gag and pol sequences encompasses the coding sequences for p24, p15, protease, reverse transcriptase, and the amino-terminus of p34 endonuclease. This construct, designated pEVdl443, expressed HIV-1 envelope glycoproteins and Tat protein and encodes the regulatory gene products Nef and Rev, as well as Vpu, Vpr, Vif, and a pl7/p34 fusion gene product. In addition to transgenic line 26, lines 22c and 25 were also established.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations