Allele/Variant

Hpgdtm1Ljm

Species
Mus musculus
Symbol
Hpgdtm1Ljm
Category
allele
Allele of gene
Hpgd
Transgenic Constructs
None
Synonyms
  • HpgdH
Description
In the process of creating a loxP-flanked allele, a tandem duplication of exon 1 and 2 with an frt-flanked neo cassete and a 5' loxP site inserted into intron 2 was knocked into the gene. The authors state that this allele is hypomorphic. Northern blot analysis confirmed reduced transcript levels in the lungs and the absence of transcript in the liver and placenta of E17.5 embryos. Enzymatic assays confirmed decreased activity in the adult lungs, liver and E15.5 placenta.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations