Allele/Variant

Tg(tetO-Mcpt1)1Mrab

Species

Mus musculus

Symbol

Tg(tetO-Mcpt1)1Mrab

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

RVCH+
TRE-RVCH-HA

Description

The transgene was designed with the tetracycline-responsive element (TRE; also called tet-operator or tetO) upstream of a rat vascular chymase (RVCH or Mcpt1) gene modified such that a human influenza hemagglutinin (HA) tag is added to the C terminus of mature RVCH protein. With the addition of dox expression of the RVCH-HA fusion protein can be completely abolished, reversing the hypertension phenotype.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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