Kcnq1ot1^tm2Tilg

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Species

Mus musculus

Symbol

Kcnq1ot1^tm2Tilg

Category

allele

Allele of gene

Kcnq1ot1

Transgenic Constructs

None

Synonyms

• Promdelta

Description

244 bp of the gene promoter was deleted and a self-excising selection cassette was placed downstream of the gene. The deleted sequence included two of the three DNAse hypersensitive sites in the promoter and the gene transcription start site but left most of the CpG island intact. After recombination and generation of chimeric mice, the selection cassette excised itself in the male germline leaving behind a single loxP site. Heterozygous mice that inherit the deletion paternally do not express the gene transcript as determined by RNAse protection assay.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations