Kcnq1ot1^tm4Tilg

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Species

Mus musculus

Symbol

Kcnq1ot1^tm4Tilg

Category

allele

Allele of gene

Kcnq1ot1

Transgenic Constructs

None

Synonyms

• Repdelta

Description

Five evolutionarily conserved 30-bp repeated sequences in the proximal end of the transcript were deleted in a 657 bp region. A self-excising selection cassette was also placed downstream of the gene. After recombination and generation of chimeric mice, the selection cassette excised itself in the male germline leaving behind a single loxP site. Heterozygous mice that inherit the deletion paternally transcribe a truncated RNA that is missing the 657 bp of sequence but is otherwise a full length transcript.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations