Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Nkx2-1-cre)2Sand
MGI:3773076Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Nkx2-1-cre)2Sand

Species
Mus musculus
Symbol
Tg(Nkx2-1-cre)2Sand
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Nkx2-1BACCre
  • Nkx2.1-cre
Description
A mouse BAC clone containing the Nkx2-1 gene was engineered to express cre recombinase. Fifteen base pairs at the 5'end of exon 2 of the Nkx2-1 gene were replaced with a cre-poly(A) construct. The mutated BAC clone was then used to generate transgenic mice. This construct is expressed in brain, thyroid, pituitary, and lung, with telecephalic expression first detectable at E10.5.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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