Irak4^m1Btlr

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Species

Mus musculus

Symbol

Irak4^m1Btlr

Category

allele

Allele of gene

Irak4

Transgenic Constructs

None

Synonyms

• otiose

Description

The otiose mutation, which was identified in an ENU mutagenesis screen for mutants with altered responses to Toll-like receptor (TLR) ligands, corresponds to a T to C transition at nucleotide position 1095 of the gene, in exon 9 of 12 total exons. No immunoreactive protein is detected by western blot analysis of mutant macrophages, and immunoprecipitated protein from mutant macrophages exhibits no kinase activity in vitro.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations