Allele/Variant

Clnktm1Rygo

Species
Mus musculus
Symbol
Clnktm1Rygo
Category
allele
Allele of gene
Clnk
Transgenic Constructs
None
Synonyms
  • MISTdeltaneo
Description
Exon 2, containing the start methionine, was replaced with an EGFP and floxed neo cassette. The neo cassette was removed by transient cre-mediated recombination. The absence of protein product was confirmed by western blot analysis on spleen NK and NKT cell extracts and mast cell extracts.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal interferon-gamma secretion
MGI
abnormal NK T cell physiology
MGI
decreased interleukin-4 secretion
MGI
increased interferon-gamma secretionMGI
increased natural killer cell mediated cytotoxicityMGI
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Disease Associations