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Date: Tue Jan 28 2025
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Gt(ROSA)26Sor
tm1(ptxA)Cgh
MGI:3776029
Allele of
Gt(ROSA)26Sor
Mus musculus
Summary
Transgenic Constructs
Genomic Variant Information
Variant Molecular Consequences
Phenotypes
Disease Associations
Allele/Variant
Gt(ROSA)26Sor
tm1(ptxA)Cgh
Species
Mus musculus
Symbol
Gt(ROSA)26Sor
tm1(ptxA)Cgh
Category
allele
Allele of gene
Gt(ROSA)26Sor
Transgenic Constructs
None
Synonyms
ROSA26
PTX
Description
A splice acceptor, floxed neo cassette and ptxA (pertussis toxin subunit 1) were knocked into intron 1. Removal of the neo cassette by cre-mediated recombination will result in the expresson of ptxA.
Additional Information
Literature
Transgenic Constructs
No data available
Genomic Variant Information
No data available
Variant Molecular Consequences
No data available
Phenotypes
Phenotype
Clear
Apply
Annotation details
Source
Clear
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References
Clear
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abnormal glucose homeostasis
View
Name
Type
Experimental condition
Modifier
References
Gt(ROSA)26Sor
tm1(ptxA)Cgh
/Gt(ROSA)26Sor
+
Tg(Ins2-cre)25Mgn/0 [background:] involves: 129P2/OlaHsd * C57BL/6 * DBA/2
genotype
PMID:17992256
MGI
PMID:17992256
abnormal neural tube closure
View
Name
Type
Experimental condition
Modifier
References
Grhl3
tm1(cre)Cgh
/Grhl3
+
Gt(ROSA)26Sor
tm1(ptxA)Cgh
/Gt(ROSA)26Sor
+
[background:] involves: 129P2/OlaHsd * C57BL/6 * SJL
genotype
PMID:20152175
MGI
PMID:20152175
exencephaly
View
Name
Type
Experimental condition
Modifier
References
Grhl3
tm1(cre)Cgh
/Grhl3
+
Gt(ROSA)26Sor
tm1(ptxA)Cgh
/Gt(ROSA)26Sor
+
[background:] involves: 129P2/OlaHsd * C57BL/6 * SJL
genotype
PMID:20152175
MGI
PMID:20152175
hypoglycemia
View
Name
Type
Experimental condition
Modifier
References
Gt(ROSA)26Sor
tm1(ptxA)Cgh
/Gt(ROSA)26Sor
+
Tg(Ins2-cre)25Mgn/0 [background:] involves: 129P2/OlaHsd * C57BL/6 * DBA/2
genotype
PMID:17992256
MGI
PMID:17992256
improved glucose tolerance
View
Name
Type
Experimental condition
Modifier
References
Gt(ROSA)26Sor
tm1(ptxA)Cgh
/Gt(ROSA)26Sor
+
Tg(Pdx1-cre)6Cvw/0 [background:] involves: 129P2/OlaHsd * C57BL/6 * CBA
genotype
PMID:17992256
Gt(ROSA)26Sor
tm1(ptxA)Cgh
/Gt(ROSA)26Sor
+
Tg(Ins2-cre)25Mgn/0 [background:] involves: 129P2/OlaHsd * C57BL/6 * DBA/2
genotype
PMID:17992256
MGI
PMID:17992256
increased circulating insulin level
View
Name
Type
Experimental condition
Modifier
References
Gt(ROSA)26Sor
tm1(ptxA)Cgh
/Gt(ROSA)26Sor
+
Tg(Ins2-cre)25Mgn/0 [background:] involves: 129P2/OlaHsd * C57BL/6 * DBA/2
genotype
PMID:17992256
MGI
PMID:17992256
no abnormal phenotype detected
View
Name
Type
Experimental condition
Modifier
References
Gt(ROSA)26Sor
tm1(ptxA)Cgh
/Gt(ROSA)26Sor
tm1(ptxA)Cgh
[background:] involves: 129P2/OlaHsd * C57BL/6
genotype
PMID:17992256
MGI
PMID:17992256
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