Version: 8.0.0
Date: Tue Jan 28 2025
Ldhaa-m11Neu
MGI:3776298
Allele of Ldha
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Ldhaa-m11Neu

Species
Mus musculus
Symbol
Ldhaa-m11Neu
Category
allele
Allele of gene
Ldha
Transgenic Constructs
None
Synonyms
  • LDH 215
  • Ldh1a11Neu
Description
Radiation-induced mutagenesis resulted in 2 transitions and 1 transversion at condon 318 (AGC to AGT), codon 319 (GCA to GAA) and codon 321 (ACC to AGC) that caused amino acid substitutions of glutamic acid for alanine at position 319 (A319E) and serine for threonine at position 321 (S321T). The transition at codon 318 is silent. Enzyme activity is decreased to 61% of wild-type in heterozygotes and 18% of wild-type in homozygotes.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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