Version: 8.0.0
Date: Tue Jan 28 2025
Gt(ROSA)26Sortm1(Tfrc*)Nca
MGI:3778905
Allele of Gt(ROSA)26Sor
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Gt(ROSA)26Sortm1(Tfrc*)Nca

Species
Mus musculus
Symbol
Gt(ROSA)26Sortm1(Tfrc*)Nca
Category
allele
Allele of gene
Gt(ROSA)26Sor
Transgenic Constructs
Synonyms
  • ROSA26Tfr1R654A
Description
A Tfrc cDNA containing a point mutation that resulted in the amino acid substitution of alanine for arginine at position 654 (R654A) was knocked into the ROSA locus along with a floxed neo cassette. The neo cassette was subsequently removed by germ-line, cre-mediated recombination. This point mutation prevents binding to Tf but does not alter the interaction with Hfe.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
    References
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