Allele/Variant

Tfrctm2Nca

Species
Mus musculus
Symbol
Tfrctm2Nca
Category
allele
Allele of gene
Tfrc
Transgenic Constructs
None
Synonyms
  • Tfr1L622A
Description
Exon 17 was replaced with one in which a nucleotide susbtitution resulted in an amino acid substitution of alanine for leucine at position 622 (L622A). A floxed neo cassette was also inserted downstream of exon 17 but was subsequently removed by germ-line, cre-mediated recombination. This mutation prevents binding to Hfe but does not interfer with binding to Tf.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations