Allele/Variant

Tg(ACTB-SOD2)66Ysh

Species

Mus musculus

Symbol

Tg(ACTB-SOD2)66Ysh

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

MnSOD-Tg
Tg(HMS)66

Description

cDNA for human mitochondrial superoxide dismutase (MnSOD or SOD2) was placed downstream of a human beta actin promoter and a 5' flanking sequence. The construct contained intron 1 sequence of the human beta actin gene to allow RNA splicing to occur. Line 66 was established. RNA blot analysis showed a 1.4 kb human MnSOD mRNA expressed in the mouse heart. Enzymatic activity in the heart is increased 325% relative to wild-type.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

SOD2 (Hsa)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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