Allele/Variant

Fgf16tm1(cre)Sms

Species
Mus musculus
Symbol
Fgf16tm1(cre)Sms
Category
allele
Allele of gene
Fgf16
Transgenic Constructs
Synonyms
  • Fgf16IRESCreNeo
Description
The Cre recombinase coding sequence, preceded by an internal ribosomal entry site (IRES) and followed by a frt-flanked neomycin resistance cassette, interrupts exon 1 so as to disrupt codon 63. RT-PCR using primers to sequences upstream of the insertion site and in exon 2 detects the expected Fgf16 transcripts in E9.0 wild-type and heterozygous female embryos, but none in hemizygous male embryos. Cre recombinase is not expressed from this allele. Crossing mice bearing this allele with mice expressing FLPe recombinase yields progeny in which the neo cassette has been excised and Cre recombinase is expressed under control of the endogenous Fgf16 promoter.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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