Map3k8^M1Btlr

---

Species

Mus musculus

Symbol

Map3k8^M1Btlr

Category

allele

Allele of gene

Map3k8

Transgenic Constructs

None

Synonyms

• sluggish

Description

This mutation was identified in a screen of G3 progeny of ENU mutagenized male mice for altered responses to toll-like receptor (TLR) ligands. The mutation is a T to A transversion in the acceptor splice site of intron 4 (TTGCAG --> TAGCAG), at nucleotide position 13346 of the genomic sequence (Genbank accession NC_000084). Three differently spliced transcripts have been observed in the mutant mice, one of which is similar in size to the wild type mRNA. One of the aberrant splicing events skips exon 5 and causes a frame shift. The second abnormal splicing event joins exon 3 to exon 6 in-frame, skipping exons 4 and 5.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations