Allele/Variant

Map3k8M1Btlr

Species
Mus musculus
Symbol
Map3k8M1Btlr
Category
allele
Allele of gene
Map3k8
Transgenic Constructs
None
Synonyms
  • sluggish
Description
This mutation was identified in a screen of G3 progeny of ENU mutagenized male mice for altered responses to toll-like receptor (TLR) ligands. The mutation is a T to A transversion in the acceptor splice site of intron 4 (TTGCAG --> TAGCAG), at nucleotide position 13346 of the genomic sequence (Genbank accession NC_000084). Three differently spliced transcripts have been observed in the mutant mice, one of which is similar in size to the wild type mRNA. One of the aberrant splicing events skips exon 5 and causes a frame shift. The second abnormal splicing event joins exon 3 to exon 6 in-frame, skipping exons 4 and 5.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

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