Allele/Variant

Tg(FXN)YG8Pook

Species
Mus musculus
Symbol
Tg(FXN)YG8Pook
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • YG8
Description
The transgenic construct consists of a 370kb YAC insert that includes the entire human FXN gene with GAA triplet repeat sequences, and was injected into fertilized CBA X C57BL/6 hybrid fertilized oocytes. Founder line YG8 was established, carrying 2 tandem copies of the human FXN gene with two GAA trinucleotide repeat sequences of 82 and 190 repeats. This line displayed a transmission rate of 52% to offspring.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations

Association
Disease Qualifier
Disease
Annotation details
Evidence
Source
References
is implicated inFriedreich ataxia
  • TAS
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