Allele/Variant

Gria1tm2Rsp

Species
Mus musculus
Symbol
Gria1tm2Rsp
Category
allele
Allele of gene
Gria1
Transgenic Constructs
None
Synonyms
  • GluR-A2lox
  • GluR1flox
Description
A floxed neo cassette was inserted 700 bp into exon 11 along with an additional loxP site inserted upstream of exon 10. This allele was used to generate Gria1tm1Rsp by transfecting targeted ES cells with a cre-expressing vector (pMC-cre).
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal excitatory postsynaptic potentialMGI
abnormal glutamate-mediated receptor currentsMGI
abnormal miniature excitatory postsynaptic currentsMGI
abnormal nervous system electrophysiologyMGI
abnormal spatial working memoryMGI
enhanced conditioned place preference behaviorMGI
impaired ability to fire action potentialsMGI
reduced AMPA-mediated synaptic currentsMGI
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Disease Associations

No data available