Rnf8^{Gt(RRR260)Byg}

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Species

Mus musculus

Symbol

Rnf8^{Gt(RRR260)Byg}

Category

allele

Allele of gene

Rnf8

Transgenic Constructs

None

Synonyms

• RNF8^-

Description

The gene trap vector is inserted after exon 4, disrupting proper transcription of the gene and generating a fusion product of beta-geo and the N-terminal part of the encoded protein without its C-terminal RING domain which is critical for function. The absence of protein expression was confirmed by western blot analysis on thymocyte extracts.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations